Altered bone remodeling in psoriatic arthritis
نویسندگان
چکیده
منابع مشابه
Altered Bone Biology in Psoriatic Arthritis
Psoriatic arthritis (PsA) is characterized by focal bone erosions mediated by osteoclasts at the bone-pannus junction. The bulk of research over the past decade has centered on mechanisms that underlie osteoclastogenesis along with new insights into osteoimmunology; however, recent advances that focus on steps that lead to new bone formation are beginning to emerge. New revelations about bone f...
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Background: Changes in patients’ bone mineral density (BMD) is one of the problems in patients with rheumatoid arthritis, which can be due to the use of corticosteroid drugs to reduce patients' symptoms or due to the aging process in patients. In this study, we decided to compare BMD in patients with psoriatic arthritis and rheumatoid arthritis. Methods: This study as a cross-sectional descrip...
متن کاملCirculating mediators of bone remodeling in psoriatic arthritis: implications for disordered osteoclastogenesis and bone erosion
INTRODUCTION Diverse bone pathologies are observed in patients with psoriatic arthritis (PsA). Uncoupling of bone remodeling with disordered osteoclastogenesis has been implicated in the pathogenesis of PsA. The aim of this study was to examine the role of soluble mediators of bone remodeling within the circulation of patients with PsA. METHODS Patients with PsA (n = 38), with psoriasis (n = ...
متن کاملRANKL/RANK/OPG molecular complex--control factors in bone remodeling in psoriatic arthritis.
AIM To investigate the blood levels of bone remodeling factors (RANKL, OPG and Bone-ALP) in psoriatic arthritis patients. MATERIAL AND METHODS Included in this study were 27 patients with psoriatic arthritis (CASPAR classification criteria) and 20 healthy subjects. The RANKL , OPG and Bone-ALP levels have been quantified by ELISA method. RESULTS Peripheral blood concentrations were higher i...
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Psoriatic arthritis (PsA) is a spondyloarthritis (SpA) which occurs in patients with skin and/or nail psoriasis [1]. In 20% of all cases, articular involvement precedes the onset of skin rash, a condition called ‘‘PsA sine psoriasis’’, which is commonly characterized by the occurrence of dactylitis, including the distal interphalangeal (DIP) joints [1]. Arthritis precedes the skin lesion by mor...
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ژورنال
عنوان ژورنال: Current Rheumatology Reports
سال: 2008
ISSN: 1523-3774,1534-6307
DOI: 10.1007/s11926-008-0050-5